Parameter Estimation for Crystallization Processes Using Taylor Method

Crystallization is a key unit operation that finds extensive applications in pharmaceutical, food and fine chemicals industries . The operating conditions of the crystallization process have a direct effect on the purity, size distribution, shape and polymorphic form of the crystals. These properties in turn affect the efficiencies of the downstream operations such as filtration, drying and formulating, and product effectiveness such as dissolution rate, bio-availability and toxicity . Therefore, batchto-batch uniformity of the crystal properties is important from a consumer and regulatory point of view .